這是人胰高血糖素樣肽-1(GLP-1)的合成類似物,并用作GLP-1受體Agonist1。利拉魯肽通過將精氨酸代替341位的賴氨酸是與天然人類GLP-1同源的97%。通過將C-16脂肪酸(棕櫚酸)與谷氨酸間隔劑連接在肽前蛋白26的剩余賴氨酸殘基上的C-16脂肪酸(棕櫚酸)來制造。
It is a synthetic analogue of human glucagon-like peptide-1 (GLP-1) and acts as a GLP-1 receptor Agonist1. Liraglutide is 97% homologous to natural human GLP-1 by substituting arginine for lysine at position 341. It is manufactured by connecting the C-16 fatty acid (palmitic acid) with a glutamate spacer to the C-16 fatty acid (palmitic acid) on the remaining lysine residue of the peptide preprotein 26.